Clinical Trials

Clinical trials are a necessary part of the process of developing new approaches to treating retinal conditions and help us understand retinal diseases more thoroughly. The specific trials we are conducting change regularly, but are all focused on optimizing outcomes for patients with retinal diseases. There are many potential benefits to participating in a clinical trial, including helping to advance the field of retinal diseases which include the most common causes of blindness in the USA and most developed countries around the world. Each clinical study has specific criteria that participants must meet. If you’re interested in participating in a clinical trial, please ask your doctor

 

Ongoing Clinical Trials in Follow-Up

 

Wet Age-Related Macular Degeneration

 

NCT03150589: SB11-G31-AMD

A Phase III Randomized, Double-masked, Parallel Group, Multicenter Study to Compare the Efficacy, Safety, Pharmacokinetics and Immunogenicity Between SB11 and Lucentis® in Subjects With Neovascular Age-related Macular Degeneration

 

NCT03345082: OPT-302-1002

A Phase II Dose-Ranging Study of Intravitreal OPT-302 in Combination With Ranibizumab, Compared With Ranibizumab Alone, in Participants With Neovascular Age-Related Macular Degeneration

 

NCT03539549: Maple

Phase II Study Evaluating Abicipar for Safety and Treatment Effect in Patients With Neovascular Age-related Macular Degeneration (AMD)

 

NCT 02462928: Cedar

A Phase III Safety and Efficacy Study of Abicipar Pegol (AGN-150998) in Patients With Neovascular Age-related Macular Degeneration

 

NCT 03465709: Furlong

A Phase Ib/II, 18-Month, Multi-Center, Open Label Study to Evaluate the Safety of Intravitreal APL-2 Therapy in Patients With Neovascular Age-Related Macular Degeneration (AMD)

 

NCT03677934: Archway

A Phase III, Multicenter, Randomized Visual Assessor Masked, Active-Comparator Study Of The Efficacy, Safety, And Pharmacokinetics Of The Port Delivery System With Ranibizumab In Patients With Neovascular Age-Related Macular Degeneration

 

NCT03748784: ADVM-022-02/Adverum

An Open Label Phase I Study of ADVM-022 (AAV.7m8-aflibercept) in Neovascular (Wet) Age-Related Macular Degeneration

 

Dry Age-Related Macular Degeneration

 

NCT02686658: OPH2003

A Phase II/III Randomized, Double Masked, Controlled Trial to Assess the Safety and Efficacy of Intravitreous Administration of Zimura® (Anti-C5 Aptamer) in Subjects with Geographic Atrophy Secondary to Dry Age-Related Macular Degeneration

 

NCT 02462889: Pro-Con

Phase II, Prospective, Single-Blind, Randomized Study to Evaluate Intravitreal Aflibercept Injection (IAI) Versus Sham as PROphylaxis Against CONversion to Neovascular Age-Related Macular Degeneration (AMD) in High-Risk Eyes

 

Diabetic MAcular Edema

 

NCT03511898: THR-149-001

A Phase I, open-label, multicenter, dose escalation study to evaluate the safety of a single intravitreal injection of THR-149 for the treatment of diabetic macular edema (DME)

Diabetic Retinopathy

 

NCT03531294: Prime

A Phase II Randomized, Open Label Study to Evaluate Safety of Intravitreal Aflibercept as Indicated by Real-Time Objective Imaging to Achieve Diabetic Retinopathy Improvement

 

NCT 02863354: Recovery

Intravitreal Aflibercept for Retinal Non-Perfusion in Proliferative Diabetic Retinopathy

 

NCT 03197870: Time2B

Phase II, Double-Masked, Placebo-Controlled Study to Assess the Safety and Efficacy of Subcutaneously Administered AKB-9778 15mg Once Daily or 15mg Twice Daily for 12 Months in Patients With Moderate to Severe Non-Proliferative Diabetic Retinopathy

 

NCT unavailable: DRCR.net Protocol AA

Peripheral Diabetic Retinopathy (DR)Lesions on Ultrawide-field Fundus Images and Risk of DR Worsening Over Time

 

NCT 01909791: DRCR.net Protocol V

Treatment for Central-Involved Diabetic Macular Edema in Eyes With Very Good Visual Acuity

 

NCT 02634333: DRCR.net Protocol W

Intravitreous Anti-Vascular Endothelial Growth Factor Treatment for Prevention of Vision Threatening Diabetic Retinopathy in Eyes at High Risk

 

NCT 02718326: Panorama

A Phase III, Double-Masked, Randomized Study of the Efficacy and Safety of Intravitreal Aflibercept Injection in Patients With Moderately Severe to Severe Nonproliferative Diabetic Retinopathy

 

Retinal Vein Occlusion

 

NCT03790852: KSI-CL-101/Kodiak

A Phase 1/1b Open Label, Multi-center Exploratory Study to Investigate the Bioactivity, Ocular and Systemic Safety, Tolerability, and Pharmacokinetics Following Single and Multiple Intravitreal Administrations of KSI-301 in Subjects With Wet Age-Related Macular Degeneration (wAMD), Diabetic Macular Edema (DME) and Retinal Vein Occlusion (RVO)

 

UVEITIS

NCT03131154: ADX-102-UV-005

A Phase III Randomized, Double-Masked, Vehicle-Controlled Trial to Evaluate the Safety and Efficacy of ADX-102 Ophthalmic Solution in Subjects with Non-Infectious Anterior-Uveitis